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Generic bupropion cost $25 for 10 mg, or $10 per mg tablet. In other words, patients would pay more than $10 for every 10-mg tablet. comparison, the average price of $3.50 per pill a generic formulation of bupropion is higher than that of $3.24 per tablet for Zoloft, an antidepressant approved women, according to IMS Health, a health-care research firm. In January, Zoloft was pulled from the market by a generic company. Drugmakers are under considerable pressure to keep price increases under control. Last week, an IMS analysis found that drug prices were rising at the fastest pace in nearly a decade, with generics now accounting for Cheapest viagra in uk more than 50 percent of sales. Many experts say that generic alternatives are available for patients as well. "The price of most drugs may continue to go up for some time, but generic drugs are coming very close to the price of brand-name drugs," said Dr. Peter Bach, senior medical director for pharmacy services at the nonprofit Health Research Institute in Arlington. He said patients can find generic versions of most the drugs covered by Medicare — at least the brand name drugs, he said. But some generics — such as newer antidepressant drugs — have relatively high pricing because their formulations, such as when they are administered intravenously, more costly. The FDA has given antidepressant Prozac generic manufacturer Wyeth 12 months to address "price increases that may be inappropriate for patients on this product," according to a March 8 federal letter obtained by The Times. But Dr. Bach said that Prozac's generic drug competitors are also under pressure to lower the prices or risk losing FDA approval. "If they were allowed to keep the price increases, this is a market-based issue," he said. "If the companies did not charge a certain amount per pill, they would drop out of the market." FDA officials have said they are continuing to review generic options for depression. But drugmakers have already shifted to other antidepressants and antipsychotics. At the end of March, FDA approved a generic version of the drug clomipramine, which has been found to help improve moods in some patients. And the agency approved a generic version of the antidepressant bupropion. Some experts say generic versions of antidepressants can make patients even sicker, leading to overdose and deaths. For example, a 2013 study published in the Journal of Clinical Psychiatry found that the antidepressant Cymbalta may increase fatal overdoses by a factor of five. Those deaths could have been prevented had patients received an additional antidepressant with the antidepressant, study said, adding that the cost of antidepressant to Cymbalta would have increased the cost of drug by 18 percent or more. When IMS Health asked patients to choose among generic antidepressant drugs and three brand-name antidepressants for which the company had additional pricing information, only the generic versions had a statistically meaningful lead in overall price. Patient Response In another part of the study, patients were shown four different generic drugs. One was for $2.45 per pill, another was at $6.45 per pill, a third was at $3.30 per pill and a fourth was brand-name drug at $4.30 per pill. Among all those who received the generic antidepressants, 40 percent chose the generic drugs and 62 percent said their doctors were better at recommending the generic drugs and less likely to recommend the brand-name drugs them. Among all those who received the brand-name drugs, 39 percent chose the brand-name drugs and 65 percent said their doctors were better at recommending the brand-name drugs and more likely to recommend the generic drugs them. In a survey of 6,500 respondents last August, 60 percent.

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